Women are more susceptible to autoimmune diseases such as rheumatoid arthritis, thyroiditis, or multiple sclerosis. Macías from Guadalajara (Mexico) said that these hormones must act like the nervous system, and the problem with sclerosis is that the direct cause is not clear.
He noted that no genetic marker indicates that young women are three times more likely to suffer from this disease than men, which is why it is so difficult to detect. In addition, it is considered the main cause of non-traumatic disability in the elderly.
"The most serious thing is that it appears in very young people, especially women, between 20 and 40 years old. There are 3 women for every affected male. He said that they are usually diagnosed between 25 and 30 years old, which is the moment where the most are planning ahead and are in their productive years.
In Mexico, 12 to 20 cases per 100,000 inhabitants suffer from this chronic and inflammatory disease of the central nervous system, which in 80% of cases is manifested by an attack on myelin function. Function is spread by transmitting nerve impulses. They are left with irreversible neuronal sequelae.
He explained that between the first crisis that manifests itself as part of the body paralysis and the moment when the patient is forced to use a wheelchair, it can be 7 to 10 years, which leaves a very worrying statistic.
The academic from the University of Guadalajara also explained that those countries closest to the poles have the highest number of cases. Taking Canada as an example: there are 300 cases per 100,000 inhabitants, and there are 250 and 400 cases in Northern Europe.
Some symptoms are total or partial body paralysis for more than 24 hours, loss of vision in one eye, loss of pain, sexual dysfunction, limb weakness, persistent fatigue, cramps, cognitive impairment, tingling, intestinal problems, or loss of physical coordination.
Multiple sclerosis expert Dr. Fernando Cortés Enríquez said that there are many treatments for the disease, ranging from anti-inflammatory of the nervous system to immunosuppressants to rebuild the immune system.
Experts introduced a new drug called cladribine, which patients must take once a year for two weeks, which will make patients better comply with treatment.
The drug has been approved in Mexico and 60 countries (including the United States, the European Union, Canada, Australia, and 10 Latin American countries).
With information from EFE
Canada: You are looking to attract Argentine talents, what kind of professionals are you looking for?
Data necessary to apply to the program:
The most searched profiles:
In this area ... What items are the most sought after?
The results of the harsh confinement...
The London Stock Exchange fell 3.20% on Monday as investors feared the rebound in the British coronavirus would impose further restrictions on the economy.
London's main index, FTSE-100, fell 192.43 points to 5,814.62, with the Spain-British Airways IAG group leading the fall, with a decrease of 12.35%.
The large Rolls-Royce Company (Automotive Market) fell 8.47% after the company was informed that it was seeking to increase capital of approximately 2.5 billion pounds (2.7 billion euros) in response to the crisis, and the ITV television channel fell 7.06%.
For its part, HSBC (bank of British origin), yielded 5%. From large European media it revealed on Sunday that this company allegedly allowed fraudulent transfers of millions of dollars around the world even after learning of the fraud. According to confidential documents reported by BBC Public Channel, the UK's largest bank transferred the money to an HSBC bank account in Hong Kong in 2013 and 2014 through its US operations.
Despite bad reports and a poor financial situation for the London Stock Exchange, it was not all losses, profits were also made. Monday's winners were the mining company Fresnillo (up 1.53%) and the online supermarket Ocado (up 0.36%). Investors await the response of the government of British Prime Minister Boris Johnson to the increase in COVID-19 cases in the United Kingdom. The case increased in the next few hours by 3,899, bringing the total to 394,257. So far, 41,777 people have died, after adding 28 in 24 hours.
With information from EFE
Donald Trump and the President of Brazil ratified their alliance to combat the regime of the President of Venezuela
Jair Bolsonaro, Brazilian President, finally ratified his alliance with Donald Trump to fight against the Nicolas Maduro regime in Venezuela, noting that "We seek the common good." It was also recognized that Mike Pompeo's visit marked the close cooperation between the two countries to achieve the restoration of democracy in Venezuela.
After the president of the United States visited the border between Venezuela and the South American giant, the Brazilian president congratulated the president of the United States, Donald Trump, on Sunday for the pressure exerted by his government to overthrow the regime of Nicolas Maduro.
"I congratulate President Donald Trump for his determination to continue working, together with Brazil and other countries, to restore democracy in Venezuela," he wrote on his Twitter account, along with a file photo of both leaders, shortly before six o'clock. the morning (local time, 9 GMT).
The Brazilian president also affirmed that Pompeo's visit to local Foreign Minister Ernesto Araujo in the framework of the welcome action "represents the close ties between the two countries in the search for common interests."
Bolsonaro, after completing his visits to Suriname, Guyana, Brazil and Colombia, ended the South American alliance against the Chavista regime and this Saturday ended a three-day visit to US diplomatic leaders. In addition, he announced an additional $ 348 million as "humanitarian assistance" to resolve the crisis in his country. With these funds, since 2017, the United States has added $ 1.2 billion for humanitarian assistance and development in the context of the political, economic and social crisis, which does not include the funds provided in the context of the coronavirus pandemic.
When Pompeo traveled through Brazil, it coincided with the publication of a severe United Nations report on serious human rights violations during the Maduro dictatorship. The Brazilian opposition made some criticisms, but Foreign Minister Arauyu emphasized foreign policy in his defense. The position of the previous government was stereotyped. In a report issued by the Ministry of Foreign Affairs, he said: “Between 1999 and 2018, Brazil's diplomatic experience with Venezuela was unpleasant. This is an example of ideological blindness and slavery. The material and moral interests of the people are very disadvantageous. "
In a statement published on the official website of the Ministry of Foreign Affairs, Araujo defended the opposition of the Bolsonaro government to the Chavista dictatorship, as he noted that it had decided to “break relations with Hugo Chávez and Nicolás Maduro during the indifferent silence and cooperation shameless criminal in that regime. This may be the worst humanitarian tragedy in the history of our region in two decades. "
The foreign minister also assured that "Maduro works permanently to undermine democracy throughout South America" and denounced the persistence in Venezuela of "a regime allied with drug trafficking, terrorism and organized crime that threatens the security of the region."
“Making human rights prevail, as stipulated in the Constitution, demands that Brazil continue to raise its voice more than ever to expose the suffering of Venezuelans to world attention and work for the redemocratization of Venezuela, the only way to return to respect human rights in that country ”, he stated. And he sentenced: "We would violate the Constitution if we closed our eyes to the Venezuelan tragedy."
With Information from Infobae
Are you eager to see Spanish football? We offer you all the information you need to know in the following report so that you can be updated and attentive to news.
As we all know, the 2019/20 season of the Spanish football league has ended with the coronation of Real Madrid, but now we have to consider the next season. Although Spain's domestic game ended last Sunday, July 19, it will soon be possible to see new matches in Spanish LaLiga.
It should be remembered that the next LaLiga Championship will be organized again by the Professional Football Federation (LFP) and will be the 90th edition in history in that country. That is why in this article we will try to explain when it will start to play, who will play it and what the calendar looks like.
When does LaLiga 2020/21 start?
As the coronavirus pandemic has delayed the end of the season that finally ended on Sunday, July 19, the new event will begin in September, for the first time since the 2000-01 campaign. Specifically, this will be the 12th weekend of the ninth month of this year, as announced by the president of the LFP, Javier Tebas, in May of last year.
“The next season will start on September 12, we can't later. If there are Spanish teams qualified for the semi-finals of the Champions or Europa League, they would start up to 15 days later. We will do a Christmas day, "Tebas explained in Onda Cero.
Which teams will play LaLiga 2020/21?
The teams guaranteed to participate in the 2020/21 LaLiga season are: Athletic Club Bilbao, Atlético de Madrid, Barcelona, Betis, Cádiz, Eibar, Getafe, Granada, Huesca, Levante, Osasuna, Real Madrid, Real Sociedad, Sevilla , Valencia, Valladolid and Villarreal.
Cádiz, Elche and Huesca will come to LaLiga from the Second Division. For its part, Espanyol is the first team to stand out in the 2019/20 campaign as relegated to the second category. The "parakeets" are accompanied in the Second Division by Mallorca and Leganés.
This is how the first day will be played:
First matches will be September 12 and 13.
Alavés vs. Betis
Atlético de Madrid vs. Sevilla
Barcelona vs. Elche
Real Madrid vs. Getafe
Eibar vs. Celta de Vigo
Granada vs. Athletic Club
Valencia vs. Levante
Valladolid vs. Real Sociedad
Villarreal vs. Huesca
Cádiz vs. Osasuna
It is important to highlight: Real Madrid, Barcelona, Atlético de Madrid, Sevilla, Getafe and Elche rest after fulfilling their European commitments and qualifying for the first stage.
Barcelona vs. Real Madrid: Matchday 7, October 25, Camp Nou.
Real Madrid vs. Barcelona: Matchday 30, April 11, 2021, Santiago Bernabéu.
Madrid derby dates:
Real Madrid vs. Atlético de Madrid: Matchday 13, December 13, Santiago Bernabéu
Atlético de Madrid vs. Real Madrid: Matchday 26, March 7, 2021, Wanda Metropolitano.
Sevillian derby dates:
Betis vs. Seville: Matchday 17, January 3, 2021, Benito Villamarín
Seville vs. Betis: Matchday 27, March 14, 2021, Ramón Sánchez Pizjuán
Valencian derby dates:
Valencia vs. Levante: Matchday 1, September 13, Mestalla
Levante vs. Valencia: Matchday 27, March 14, 2021, Ciutat de Valencia
Basque derby dates:
Athletic Club vs. Real Sociedad: Matchday 16, December 30, San Mamés
Real Sociedad vs. Athletic Club: Matchday 29, April 4, 2021, Reale Arena
Nobody can ignore what Lionel Messi is as a footballer and his love for FC Barcelona (the club that formed him as a player). In recent months, his relationship with the board has not been the best, but even so, Astro Argentino still likes to wear the "culé" uniform.
The story began on September 17, 2000. Lionel Messi, accompanied by his father Jorge, got off the plane in Catalonia to prove his worth and succeed in Barcelona. Twenty years later, he became the top scorer in the club's history.
With him he won 34 championships, including four Champions League. In addition, he became one of the best footballers to step on the stadium and won 6 Golden Globes. Not even the last conflict of the “burofax” affair, through which the 33-year-old striker was about to leave the Barcelonista cast, can erase so much glory.
Carles Rexach, 72, continues to work in Barcelona as when he saw Messi's teenage actions in just a few seconds and decided to sign him, being, at that time, technical secretary: a unique milestone in the agency's career.
"Now it's easy because his superiority is too obvious, but when I saw him I said to myself: 'This guy is a phenomenon', and the first thing I thought was that if nothing strange happened to him, he shouldn't go crazy, he wouldn't have a accident, that he grew in stature, he had to go very far. Even once we signed him, we made him "cheat games," he revealed. What did they consist of? "We made him play against teams made up of much older people, but the ball he always had him, and that shyness that he had outside the playing fields would go away once it began to be played and it was another person, "he said in a dialogue with Infobae, in December 2019.
Although magic existed in his boots, his signing was not immediate or easy. "Some managers showed many obstacles because they said that Messi was very young and foreign (therefore, he could not be able to participate in the local league), but I think that my contact with the agent Josep Maria Minghella in Argentina was productive and he told me : Even though he's only 12 years old, "you must see him." But at that age and coming from so far away, I couldn't go there to see him. I told them 'let's do something, let him come to Barcelona with his family for a week and we'll see him in Barcelona', but there was an unexpected problem, that I had to go on a trip right at that moment, "Rexach described the first obstacle.
“I went as a player scout for Barcelona to the Sydney Olympics, and when I came back, they told me that the family couldn't wait any longer, and they even told me: 'He's a foosball player', then, when they arrived , I said: 'Well, tomorrow we put on a game and I see it', and as soon as I saw it, I realized that it was a phenomenon, but if you don't see it, in this case, you should go home and leave the put another, "he amused himself with his occurrence.
Even before the evidence of his talent there were more chapters in history until he confirmed his union with the Blaugranas. “I was in the first team and the boy came with his father to the club and there was no one to receive them, the days went by, they got angry, and that's when Minguella told me: 'Do something because you are going to lose it', and So I made a commitment to his father, taking a napkin from a bar and committing myself there to carry out everything promised, and so I put myself in front of everything, even to try to solve the situation of the father, who was a foreigner and He needed residency, but it was complicated, because the boy had to play as a free footballer, without a regular tournament due to his situation, although in the long run, I think that all these problems made him much stronger. It is not easy to be in La Masía being so small ”, Rexach continued the story.
The engagement date is December 14, which is not far from the formal contract. The napkin became a declaration of fidelity. Horacio Gaggioli, who represented Fabián Soldini and Martín Montero in Spain, played tennis with Rexach at the Pompeia del Mont Juic Club. Then they had lunch at the club's confectionery and Josep Maria Minguella joined the table. Gaggioli and Minguella quickly announced to Rexach the final decision they had made.
The most famous napkins in sports history read the following:
"In Barcelona, on December 14, 2000 and in the presence of Messrs. Minguella and Horacio Gaggioli, Carlos Rexach Technical Secretary of the F.C.B. undertakes under his responsibility and despite some opinions against to sign the player Lionel Messi as long as we remain in the agreed amounts".
A few days later, they formalized the document before a notary public, and Messi began to prepare to move to Catalonia to capture the legend. Where is that museum piece now? It was left in the hands of Gaggioli, who today lives in Andorra, and kept it in a safe at the Crèdit Andorrà bank.
He received many millionaire offers for this historic document: from an American company to a museum in Tokyo and a British auction house. "But I will not provide it to anyone or plan to sell it. It will only be loaned to FC Barcelona, which is visited by millions of people every year." In addition, Gaggioli told Infobae in 2018: `` I think it should be a priority together with Messi's Ballon d'Or, because that piece of paper has changed the contemporary history of the club. ''
This paper shows that this legend began on September 17, 2000.
Marketing is of daily use, therefore, it is important to be constantly updated and informed of trends. We use it for everything, be it for an individual sale or in large companies and corporations.
Therefore, do not think that it is an issue related exclusively to companies but that it is something that has a daily use and is made up of both the macro and the micro.
That is why today we will teach you everything related to Marketing.
What is marketing?
The first step in understanding what marketing is is defining concepts.
Marketing is a word derived from English, despite its inherent nature in world culture. It is related to marketing, which is ultimately a study of the causes, objectives and results of the different ways in which we handle markets.
As defined by the American Marketing Association, the term is as follows: "Marketing is an activity, a series of institutions, the process of creating, communicating, delivering and exchanging offers, which is of value to consumers, customers, partners and society as a whole ". .
Marketing and its origin
Marketing: what are your main objectives?
What is the market life cycle?
What is the product or service life cycle?
Types of Marketing
Former Facebook employee made public complaints about the manipulation of this social network worldwide
Fake news accounts on Facebook have been manipulating election campaigns around the world.
This was denounced by a former employee of the social network in a 6,600-word memorandum that he sent to his former co-workers. Data scientist Sophie Zhang said she made unsupervised decisions "that affected presidents."
"My hands are stained with blood," he wrote in the communication, part of which was published by the US media Buzzfeed.
• Facebook and Twitter target Trump accounts for coronavirus-related 'misinformation' In response, Facebook said it was working to curb bad users who abuse the social network and end inauthentic behavior.
Deception of the public In the communication, part of which was published by Buzzfeed without their permission, Zhang spoke of abuse and deception of the population.
"In the three years that I was on Facebook, I encountered multiple blatant attempts by foreign governments to abuse our platform on a large scale to mislead their own citizens and create international news on multiple occasions," Zhang wrote.
"I personally made unsupervised decisions that affected presidents and took action to enforce the law against so many prominent politicians globally that I lost count," he added.
Buzzfeed said he had shared only those parts of his statement that were in the public interest and reported that Zhang turned down a $ 64,000 severance package offered to him on the condition that he not share his memo internally.
• QAnon in Latin America: how and why groups associated with this controversial conspiracy theory have multiplied in the region In response, Facebook said it was working to combat such abuses.
"We have built specialized teams, we are working with leading experts, to prevent bad actors from abusing our systems, resulting in the elimination of more than 100 networks for coordinated inauthentic behavior," the company said.
"It is a very complicated job that these teams do full time. Working against coordinated inauthentic behavior is our priority, but we are also tackling the problems of spam and false participation," he added.
"We investigate every issue carefully, including those raised by Zhang, before taking action or going out and publicly making claims as a company," Facebook said.
Examples of jobs that the former employee refers to
• Facebook took nine months to act on the information on the use of bots (robots) to promote President Juan Orlando Hernández of Honduras.
• In Azerbaijan, the ruling political party used thousands of bots to harass the opposition.
• 10.5 million false reactions and fans were removed from high-profile politicians in Brazil and the United States in the 2018 elections.
• A NATO investigator told Facebook that he had seen Russian activity in a high-profile American political figure. profile, which Zhang deleted.
• Bottom line accounts were discovered in Bolivia and Ecuador, but the issue was not prioritized due to workload
• Zhang found and removed 672,000 bogus accounts that were targeting health ministries around the world during the pandemic.
• In India, Zhang worked to eliminate a politically sophisticated network of more than 1,000 users working to influence local elections in Delhi.
"Facebook projects an image of strength and competition to the outside world ... but the reality is that many of its actions are accidental and careless accidents," Zhang says in the message.
She says that the fact that she had to make countless decisions about many different countries affected her health and left her feeling responsible when civil unrest broke out in places where she had not prioritized action.
Her revelations come just a week after former Facebook engineer Ashok Chandwaney accused the company of profiting from hatred.
Carole Cadwalladr, a UK journalist who exposed the Cambridge Analytica scandal, tweeted: "The speed and scale of the damage Facebook is doing to democracies around the world is truly terrifying."
Analysis by Marianna Spring, Disinformation Reporter
This explosive memo confirms long-held concerns about Facebook's ability to address foreign interference and disinformation campaigns.
But while most eyes have been on Russian meddling in American politics after the 2016 election, the testimony of this former employee draws attention to democratic events beyond the West.
Facebook's failure to address disinformation in other languages has come under scrutiny during the pandemic and this new information alleges that it has had trouble tackling interference campaigns in non-English speaking countries before.
The statement also raises great concerns about the enormous responsibility given to Facebook's junior moderators, whose decisions could affect democratic events, political outcomes and the lives of people around the world.
This will undoubtedly raise concerns about Facebook's work to address interference and misinformation campaigns as the next US election approaches. But it should remind us that Facebook plays a role in democratic events outside the United States.
The market for 300 (roughly) horsepower all-wheel drive hot hatch covers is filling up. In the past two years, BMW and Mercedes-AMG have battled the M135i and A35 respectively, and Audi's latest S3 must adapt.
After defeating Volkswagen, he got off to a good start. Our first opportunity to drive this new S3 came a few months before Wolfsburg removed the cover from the R version of the Mk8 Golf.
What are the new features of the Audi S3 Sportback?
The cool look obviously matches the regular A3, with a wild front face, angled design elements on the front bumper, detailed string lights, and quad tailpipes (this really is it! Long live it!). Later. If you arrive early and order immediately, version 1 of the car will be Python Yellow with yellow accents, or Tango Red if you choose the S3 Saloon.
There are hardly any changes to the interior of the ordinary A3 door, except that the interior of the sports seats uses recyclable PET plastic bottles and the Audi Sport graphics used on the digital dashboard. The quality of the material is very good, even if it is not an ordinary Audi, and the strong curmudgeon in my heart relieves me, because the A3 has manual control of the air conditioning in the touchscreen menus of the Golf and Octavia. However, the cabin is still full of surprises and joy.
However, the highlight of the S3 is its powerful powertrain, which is familiar to fans of the Volkswagen Group. The engineering focus for the powertrain is to maintain power output, and the two teams have accomplished these tasks: The 2.0-liter turbocharged four-cylinder engine produces 306bhp and 295lb ft of power at 62mph in 4.8 seconds and 155mph. In bad shape.
Everything is predictable, so...
Of course, but there are some subtle changes to the S3's skin, which can take care of the smooth ride of the car. New technology includes the Haldex 6 disc clutch suspended under the boot floor, which distributes front and rear wheel drive in a more complicated way than systems of the last two decades. The Haldex clutch at the front of the rear axle takes up some space in the trunk; the ordinary A3 Sportback has a double-layer cargo compartment, while the S3 has a single-layer suitcase. The trunk volume is reduced from 380 to 325, but it is still a reasonable and practical way to swallow the daily hits.
Now, for the first time, the S3's Quattro system can fully drive the rear wheels into extreme positions, and the electronic brain can brake a single wheel for a torque vector effect. As you turn a slippery corner at high speed, step on the accelerator and you will feel the Audi slide into the corner, with an impressive neutral feel and high grip. Now, there are no longer different control systems for Quattro, vibration and brakes, now there is a unified digital brain that can make smoother, faster and more reliable decisions. Adaptive suspension is on the option list, as are the larger 19-inch wheels (the S3 usually turns 18). Both are only standard on toppy Vorsprung models.
Are you still that fast?
The real S3 is like your Golf R buddy, one of those racing cars that can drive fast with almost no effort. With a familiar powertrain, the S3 is like putting on an old pair of sneakers for owners of a Volkswagen Group hatchback: Despite the turbocharger technology, this engine will not receive any power increases in any power range. Impact. The number of revolutions only increased the limiter steadily by 2,000 rpm.
The dual-clutch automatic gearbox can still shift gears with flawless dexterity, but the previous model's sliding gear stick is gone, replaced by a metal cigarette case protruding from the center console. There is no manual switch or selection, but when you start to use the lever, the gearbox will lock the car in manual mode.
Compared to the previous model, the most notable change is how harsh and aggressive the engine sounds to this latest tune. When you enter the Dynamic, the noise will increase artificially, but after good judgment, the sound does not sound like a video game, with a peculiar tactical pop sound and exhaust sound that makes it very good and pleasant.
See it all: How does the latest S3 work?
Our test car has ticked the "Adaptive Damper" option box, and it is recommended that you order non-Vorsprung products. According to our conversation with the chassis engineer during the process of driving the prototype, its adjustment range has increased by about 40%, Based on our conversations with the chassis engineers during the process of driving the prototype, an adjustment can be achieved softer and cushioned ride comfort, or at the other extreme, can provide a firmer fit for the body of the vise. Control the time you play the Hannu Mikkola fantasy when you return home.
You can control many systems - dampers, steering weight, throttle response, gearbox mapping and exhaust sound - via the simple Audi Drive Select button on the dash. In "comfort" mode, the vehicle feels more relaxed and the damping setting is softer, which can absorb cobbled roads, potholes and potholes. Put it in a "dynamic" state and the steering will increase just fine, without some of the artificial loads experienced by previous systems. Compared to the previous S3, this is a significant change; Although there is still not enough feeling, this generation is more excited about the curves than before. . This kind of agility is welcome when traversing hairpin turns in the European wilderness.
The more attentive steering wheel is largely supported by the available grip jumps; even if you enter the corner too fast, the S3 is still a difficult car to go downhill.
Audi S3: verdict
The new 2020 Audi S3 continues to position it at the higher end of the hot hatch scale. The helpful pacing and grip of the engine and gearbox are enough to make your time worth your time, and these are complete, highly polished packages.
However, this all adds up to ruthless efficiency, and it's not a very good entertainment experience. I bet compared to some specially-designed sports cars the S3 can cover more ground, not to mention other popular hatchbacks, but later on, the faces of the people who make it to the end will show a bigger smile.